Sucrose-free low-fat diet induces metabolic dysfunction through gut dysbiosis and colonic inflammation in mice - Takeaways - MDSpire

Impact of a Sucrose-Excluded Low-Fat Diet on Metabolic Health via Gut Microbiome Disruption and Colonic Inflammation in Murine Models

  • By

  • Nourah Almansour

  • Shihab Kochumon

  • Fatema Al-Rashed

  • Md Zubbair Malik

  • Noelle Benobaid

  • Steve Shenouda

  • Reeby Thomas

  • Hossein Arefanian

  • Rasheeba Nizam

  • Texy Jacob

  • Ashraf Al Madhoun

  • Jaakko Tuomilehto

  • Fahd Al-Mulla

  • Rasheed Ahmad

  • July 21, 2026

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  • 1

    A sucrose-free low-fat diet (SF-LFD) in mice led to impaired glucose tolerance and reduced insulin sensitivity after 16 weeks.

  • 2

    SF-LFD feeding resulted in significant alterations in circulating metabolic hormones, including elevated C-peptide and ghrelin.

  • 3

    Gut microbial diversity was disrupted by SF-LFD, with a decrease in beneficial bacteria and an increase in inflammatory-associated taxa.

  • 4

    Colonic inflammation was pronounced in SF-LFD mice, characterized by crypt disruption and increased immune cell infiltration.

  • 5

    Hepatic inflammation and microvesicular steatosis were observed in mice fed the SF-LFD, indicating metabolic dysfunction.

Original Source(s)

Sucrose-free low-fat diet induces metabolic dysfunction through gut dysbiosis and colonic inflammation in mice

  • by Nourah Almansour, Shihab Kochumon, Fatema Al-Rashed, Md Zubbair Malik, Noelle Benobaid, Steve Shenouda, Reeby Thomas, Hossein Arefanian, Rasheeba Nizam, Texy Jacob, Ashraf Al Madhoun, Jaakko Tuomilehto, Fahd Al-Mulla, Rasheed Ahmad

  • July 21, 2026

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