Predicting neurodevelopmental outcomes in neonatal hyperbilirubinemia: a multidimensional nomogram integrating biomarkers and neurobehavioral scores - Takeaways - MDSpire

Predicting neurodevelopmental outcomes in neonatal hyperbilirubinemia: a multidimensional nomogram integrating biomarkers and neurobehavioral scores

  • By

  • Mei Xue

  • Jiansong Yin

  • Jun Lv

  • Jiaping Yu

  • Jing Wang

  • May 29, 2026

  • 0 min

Share

  • 1

    The study evaluated neurodevelopmental trajectories in 234 term neonates with hyperbilirubinemia and developed a predictive model for impairment.

  • 2

    At 12 months, 12.8% of infants showed neurodevelopmental impairment, with elevated CRP, bilirubin-to-albumin ratio, and NSE identified as risk factors.

  • 3

    Higher NBNA scores were found to be a protective factor against neurodevelopmental impairment in neonates with hyperbilirubinemia.

  • 4

    The predictive model demonstrated stable discriminative power with an AUC of 0.797, indicating its effectiveness in risk stratification.

  • 5

    The research highlights the need for targeted long-term follow-up and developmental monitoring for high-risk infants with hyperbilirubinemia.

Original Source(s)

Predicting neurodevelopmental outcomes in neonatal hyperbilirubinemia: a multidimensional nomogram integrating biomarkers and neurobehavioral scores

  • by Mei Xue, Jiansong Yin, Jun Lv, Jiaping Yu, Jing Wang

  • May 29, 2026

Related Content

Laparoscopic intracavitary catheterization combined with bleomycin quadruple sclerotherapy for retroperitoneal lymphatic malformations: a single-center case series

A pilot study combining primary busulfan-based haploidentical stem cell transplantation with GD2 antibody to treat high-risk neuroblastoma

Parents' knowledge and attitudes toward pediatric concussions in Saudi Arabia