The Role of Vitamin D, Myo-Inositol, and Melatonin in the Redox-Endocrine Network of PCOS: Exploring Their Potential Synergistic Effects - Takeaways - MDSpire

The Role of Vitamin D, Myo-Inositol, and Melatonin in the Redox-Endocrine Network of PCOS: Exploring Their Potential Synergistic Effects

  • By

  • Subakathulla, Sumayyah

  • Manoj, Norwin

  • Patanwala, Azima Muzzammil

  • Premvignesh, Prasanna Appiya

  • Maher, Yamen

  • Majie, Ankit

  • Gorain, Bapi

  • Dutta, PhD, Sulagna

  • Sengupta, PhD, Pallav

  • Maldonado Rosas, Israel

  • Roychoudhury, Shubhadeep

  • April 9, 2026

  • 0 min

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  • 1

    PCOS is a complex disorder characterized by reproductive dysfunction, insulin resistance, inflammation, and oxidative stress.

  • 2

    Vitamin D, myo-inositol, and melatonin may work together as a synergistic 'bioactive cocktail' to address PCOS.

  • 3

    These bioactives target shared molecular pathways, including NF-κB, Nrf2, PI3K/Akt, and AMPK, to improve metabolic and endocrine functions.

  • 4

    Clinical trials show variable improvements in ovulatory function and insulin resistance, influenced by dosing and patient phenotype.

  • 5

    A redox-guided, phenotype-aware approach is recommended for future trials to enhance treatment precision in PCOS.

Original Source(s)

The Role of Vitamin D, Myo-Inositol, and Melatonin in the Redox-Endocrine Network of PCOS: Exploring Their Potential Synergistic Effects

  • by Subakathulla, Sumayyah , Manoj, Norwin , Patanwala, Azima Muzzammil, Premvignesh, Prasanna Appiya, Maher, Yamen , Majie, Ankit , Gorain, Bapi , Dutta, PhD, Sulagna , Sengupta, PhD, Pallav , Maldonado Rosas, Israel , Roychoudhury, Shubhadeep

  • April 9, 2026

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