Effects of the active parts of Yangxin Tongmai Formula on myocardial injury and spatial metabolic remodeling in rats with myocardial ischemia-reperfusion injury - Takeaways - MDSpire

Impact of Yangxin Tongmai Formula's Active Components on Myocardial Damage and Spatial Metabolic Changes in Rats Experiencing Ischemia-Reperfusion Injury

  • By

  • Di Ye

  • Yi Wang

  • Ziyuan Zhao

  • Caiyue Lin

  • Wenhua Xu

  • Jinghui Zheng

  • July 20, 2026

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  • 1

    The study investigated the protective effects of Yangxin Tongmai Formula's active components against myocardial ischemia-reperfusion injury in rats.

  • 2

    Rats were divided into Control, Model, Vehicle, and apr-YTF groups, with apr-YTF administered for 14 days.

  • 3

    apr-YTF improved cardiac function, reduced serum myocardial enzyme levels, and decreased infarct size in the MIRI model.

  • 4

    MALDI-MSI identified 1,282 metabolites, revealing extensive metabolic remodeling in the MIRI group, particularly in lipid and amino acid metabolism.

  • 5

    After apr-YTF intervention, 17 differential metabolic features showed recovery trends, indicating partial correction of metabolic remodeling.

Original Source(s)

Effects of the active parts of Yangxin Tongmai Formula on myocardial injury and spatial metabolic remodeling in rats with myocardial ischemia-reperfusion injury

  • by Di Ye, Yi Wang, Ziyuan Zhao, Caiyue Lin, Wenhua Xu, Jinghui Zheng

  • July 20, 2026

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