Dual-energy and perfusion CT for predicting response to chemo-radiotherapy in head and neck cancer: an exploratory study - Takeaways - MDSpire

Dual-energy and perfusion CT for predicting response to chemo-radiotherapy in head and neck cancer: an exploratory study

  • By

  • Benjamin Van Honacker

  • Yolène Lefebvre

  • Marianne Paesmans

  • Manuela Burghelea

  • Dirk Van Gestel

  • Tatiana Dragan

  • May 5, 2026

  • 0 min

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  • 1

    Head and neck cancer (HNC) is linked to HPV, smoking, and alcohol, with HPV-positive cases showing better responses to chemoradiotherapy.

  • 2

    This study evaluated dual-energy CT (DECT) and perfusion CT (PCT) as predictive tools for treatment response in HNC patients.

  • 3

    Patients with complete response (CR) exhibited higher blood flow and blood volume at 3 weeks compared to non-CR patients.

  • 4

    In HPV-positive patients, CR was associated with significantly higher blood flow and blood volume than in non-CR patients.

  • 5

    The findings suggest DECT and PCT may serve as potential imaging biomarkers for predicting treatment outcomes in HNC.

Original Source(s)

Dual-energy and perfusion CT for predicting response to chemo-radiotherapy in head and neck cancer: an exploratory study

  • by Benjamin Van Honacker, Yolène Lefebvre, Marianne Paesmans, Manuela Burghelea, Dirk Van Gestel, Tatiana Dragan

  • May 5, 2026

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