TPPU protects against seizures and seizure-associated comorbidities by inhibiting the Akt/mTOR signaling pathway in KA-induced convulsant mice - Takeaways - MDSpire

TPPU protects against seizures and seizure-associated comorbidities by inhibiting the Akt/mTOR signaling pathway in KA-induced convulsant mice

  • By

  • Rong Tang

  • Banglian Hu

  • Sulan Xie

  • Yijun Shen

  • Ziwei Wang

  • Xingyi Wang

  • Xiaohua Huang

  • Guoqiang Fei

  • Weifeng Peng

  • Honghua Zheng

  • Jing Ding

  • Xin Wang

  • June 8, 2026

  • 0 min

Share

  • 1

    TPPU is a soluble epoxide hydrolase inhibitor that exhibits anti-inflammatory effects by preventing the hydrolysis of epoxyeicosatrienoic acids.

  • 2

    In KA-induced chronic epileptic mice, TPPU significantly mitigated seizure severity and improved anxiety, depression, and cognitive function.

  • 3

    TPPU reduced neuronal apoptosis and neuroinflammation, demonstrating neuroprotective properties in the context of epilepsy.

  • 4

    RNA-sequencing analysis revealed that TPPU protects against neuroinflammation during epileptogenesis by suppressing the Akt/mTOR pathway.

  • 5

    The study establishes the Akt/mTOR axis as a critical pathway mediating TPPU's protective actions against epilepsy and its comorbidities.

Original Source(s)

TPPU protects against seizures and seizure-associated comorbidities by inhibiting the Akt/mTOR signaling pathway in KA-induced convulsant mice

  • by Rong Tang, Banglian Hu, Sulan Xie, Yijun Shen, Ziwei Wang, Xingyi Wang, Xiaohua Huang, Guoqiang Fei, Weifeng Peng, Honghua Zheng, Jing Ding, Xin Wang

  • June 8, 2026

Related Content

2026 Brain and Spine Symposium Highlights Advances Across the Neurosciences

Over two days, specialists across neurology, neurosurgery and related subspecialties came together to discuss advances in stroke care, epilepsy, movement disorders, neurodegenerative disease, neuro-oncology, brain and spine surgery, interventional pain management and emerging technologies.

  • May 21, 2026

  • 1 min
Neurocognitive function among individuals with problematic social media use

Nurses Face High Physical, Cognitive Load in Trauma Surgery

Qualitative interviews identified four themes involving emergency challenges and response, teamwork, psychological stress and coping, and professional growth needs in trauma surgery.