TPPU protects against seizures and seizure-associated comorbidities by inhibiting the Akt/mTOR signaling pathway in KA-induced convulsant mice - Takeaways - MDSpire
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TPPU Mitigates Seizures and Associated Comorbidities by Targeting the Akt/mTOR Pathway in Mice with KA-Induced Convulsions

  • By

  • Rong Tang

  • Banglian Hu

  • Sulan Xie

  • Yijun Shen

  • Ziwei Wang

  • Xingyi Wang

  • Xiaohua Huang

  • Guoqiang Fei

  • Weifeng Peng

  • Honghua Zheng

  • Jing Ding

  • Xin Wang

  • June 8, 2026

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  • 1

    TPPU is a soluble epoxide hydrolase inhibitor that exhibits anti-inflammatory effects by preventing the hydrolysis of epoxyeicosatrienoic acids.

  • 2

    In KA-induced chronic epileptic mice, TPPU significantly mitigated seizure severity and improved anxiety, depression, and cognitive function.

  • 3

    TPPU reduced neuronal apoptosis and neuroinflammation, demonstrating neuroprotective properties in the context of epilepsy.

  • 4

    RNA-sequencing analysis revealed that TPPU protects against neuroinflammation during epileptogenesis by suppressing the Akt/mTOR pathway.

  • 5

    The study establishes the Akt/mTOR axis as a critical pathway mediating TPPU's protective actions against epilepsy and its comorbidities.

Original Source(s)

TPPU protects against seizures and seizure-associated comorbidities by inhibiting the Akt/mTOR signaling pathway in KA-induced convulsant mice

  • by Rong Tang, Banglian Hu, Sulan Xie, Yijun Shen, Ziwei Wang, Xingyi Wang, Xiaohua Huang, Guoqiang Fei, Weifeng Peng, Honghua Zheng, Jing Ding, Xin Wang

  • June 8, 2026

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