Genetic predictors of neurocognitive outcomes in survivors of pediatric brain tumors

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In 2023, an estimated 5,230 children and teens in the U.S. will be diagnosed with brain tumors, making it the second most common pediatric cancer.
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Survival rates for pediatric brain tumor patients have improved significantly, with 5-year survival reaching 75.5% from 2013 to 2019.
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Neurocognitive deficits in survivors are influenced by treatment-related factors and genetic abnormalities, necessitating better predictive markers.
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The study genotyped 46 children treated for brain tumors to explore associations between genetic variants and IQ outcomes.
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Results indicated that 56% of participants had an IQ below 90, highlighting the need for targeted interventions in at-risk pediatric patients.

Journal Of Neuro-Oncology

by Sydney T. Grob, Kristen R. Miller, Bridget Sanford, Andrew M. Donson, Kenneth Jones, Andrea M. Griesinger, Vladimir Amani, Nicholas K. Foreman, Arthur Liu, Michael Handler, Todd C. Hankinson, Sarah Milgrom, Jean M. Mulcahy Levy
October 25, 2023

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