Validation of ICD-10-CM algorithms for repeated eGFR-defined chronic kidney disease in the TriNetX network - Takeaways - MDSpire
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Assessing ICD-10-CM Algorithms for Repeated eGFR-Defined Chronic Kidney Disease in the TriNetX Network

  • By

  • Chung-An Wang

  • Wei-Jie Wang

  • Jui-Yi Chen

  • Chung-Yi Cheng

  • Vin-Cent Wu

  • October 13, 2026

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  • 1

    The study evaluated ICD-10-CM algorithms against repeated eGFR-defined CKD in 8,239,691 adults in the TriNetX US Collaborative Network.

  • 2

    Among participants, 1,328,952 met laboratory criteria for CKD stage 3 or higher.

  • 3

    For CKD stage 3 or higher, one ICD-10-CM code had 64.1% sensitivity, 95.6% specificity, 73.8% positive predictive value, and 93.3% negative predictive value.

  • 4

    Requiring at least 2 codes or restricting code ascertainment to ±3 to ±12 months increased positive predictive value and decreased sensitivity.

  • 5

    Temporal restriction raised positive predictive value to approximately 96% for stage 3 or higher and 93% for stage 4 or higher, but no single phenotype was universally optimal.

Original Source(s)

Validation of ICD-10-CM algorithms for repeated eGFR-defined chronic kidney disease in the TriNetX network

  • by Chung-An Wang, Wei-Jie Wang, Jui-Yi Chen, Chung-Yi Cheng, Vin-Cent Wu

  • October 13, 2026

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