Testosterone and Androgen Receptor Pathway Modulation in Sepsis: Immunometabolic Mechanisms and Therapeutic Implications — A Scoping Review - Takeaways - MDSpire

Testosterone and Androgen Receptor Pathway Modulation in Sepsis: Immunometabolic Mechanisms and Therapeutic Implications — A Scoping Review

  • By

  • Szczupak, Mateusz

  • Kobak, Jacek

  • Kreczko, Mateusz

  • Wierzchowska, Jolanta

  • Krupa-Nurcek, Sabina

  • April 21, 2026

  • 0 min

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  • 1

    Sepsis is characterized by a dysregulated host response to infection, leading to high mortality rates.

  • 2

    Testosterone may modulate the immunometabolic response in sepsis, with lower levels linked to increased disease severity.

  • 3

    Thirteen studies were included in the review, showing a correlation between testosterone levels and patient outcomes.

  • 4

    Clinical studies on testosterone supplementation showed changes in metabolic parameters but no significant survival benefits.

  • 5

    Further research is needed to explore personalized hormonal interventions in sepsis, considering sex-specific factors.

Original Source(s)

Testosterone and Androgen Receptor Pathway Modulation in Sepsis: Immunometabolic Mechanisms and Therapeutic Implications — A Scoping Review

  • by Szczupak, Mateusz , Kobak, Jacek , Kreczko, Mateusz , Wierzchowska, Jolanta , Krupa-Nurcek, Sabina

  • April 21, 2026

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