Late enhancement and washout maps for distinguishing tumor progression from radiation necrosis in malignant brain tumors: an exploratory study - Takeaways - MDSpire
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An Exploratory Study of Late Enhancement and Washout Maps to Differentiate Tumor Progression from Radiation Necrosis in Malignant Brain Tumors

  • By

  • Eya Khadhraoui

  • Leon Schmidt

  • Stefan Klebingat

  • I Erol Sandalcioglu

  • Roland Schwab

  • Philipp Arndt

  • Daniel Behme

  • Klaus-Peter Stein

  • Sebastian Johannes Müller

  • October 15, 2026

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  • 1

    Posttreatment enhancement on conventional MRI can reflect tumor progression, radiation necrosis, or pseudoprogression, complicating response assessment.

  • 2

    The study evaluated whether delayed-enhancement imaging could help distinguish tumor progression from radiation necrosis in malignant brain tumors.

  • 3

    The protocol acquired contrast-enhanced 3D T1-weighted images at approximately 5 to 9 minutes and 25 to 29 minutes after contrast administration.

  • 4

    Washout maps were generated by coregistering and normalizing the two T1-weighted datasets, then subtracting corresponding voxels; red indicated washout and green indicated delayed enhancement.

  • 5

    The retrospective, single-center study included adults with selected malignant brain tumors and new enhancing lesions on follow-up MRI after surgery and radiochemotherapy.

Original Source(s)

Late enhancement and washout maps for distinguishing tumor progression from radiation necrosis in malignant brain tumors: an exploratory study

  • by Eya Khadhraoui, Leon Schmidt, Stefan Klebingat, I Erol Sandalcioglu, Roland Schwab, Philipp Arndt, Daniel Behme, Klaus-Peter Stein, Sebastian Johannes Müller

  • October 15, 2026

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