Functional and Structural Characterization of Treatment-Emergent Nirmatrelvir Resistance Mutations at Low Frequencies in the Main Protease (Mpro) Reveals a Unique Evolutionary Route for SARS-CoV-2 to Gain Resistance - Top-Institutions - MDSpire

Functional and Structural Characterization of Treatment-Emergent Nirmatrelvir Resistance Mutations at Low Frequencies in the Main Protease (Mpro) Reveals a Unique Evolutionary Route for SARS-CoV-2 to Gain Resistance

  • By

  • Natalie M Deschenes

  • Jimena Pérez-Vargas

  • Zoe Zhong

  • Merrilee Thomas

  • Calem Kenward

  • Wesley A Mosimann

  • Liam J Worrall

  • Nicholas Waglechner

  • Angel XinLiu Li

  • Finlay Maguire

  • Patryk Aftanas

  • Jason R Smith

  • Jared Lim

  • Robert N Young

  • Artem Cherkasov

  • Lubna Farooqi

  • Adnan Moinuddin

  • Lina Siddiqi

  • Imaan Malik

  • Maxime Lefebvre

  • Mark Paetzel

  • Natalie C J Strynadka

  • François Jean

  • Allison McGeer

  • Robert A Kozak

  • June 3, 2025

  • 0 min

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Top Institutions in Infectious Disease

Brief introduction explaining scope and methodology.

  • #1

    Broad Institute of MIT and Harvard
    Broad Institute of MIT and Harvard

    Cambridge, MA

    Key Differentiators

    • Virology
    • Genomics
    • Structural Biology

  • #2

    National Institute of Allergy and Infectious Diseases (NIAID), NIH
    National Institute of Allergy and Infectious Diseases (NIAID), NIH

    Bethesda, MD

    Key Differentiators

    • Infectious Diseases
    • Antiviral Drug Development
    • Molecular Virology

  • #3

    University of Washington, Institute for Protein Design
    University of Washington, Institute for Protein Design

    Seattle, WA

    Key Differentiators

    • Structural Biology
    • Protein Engineering
    • Virology

  • #4

    Johns Hopkins University School of Medicine
    Johns Hopkins University School of Medicine

    Baltimore, MD

    Key Differentiators

    • Infectious Diseases
    • Clinical Virology
    • Pharmacology

  • #5

    University of California, San Francisco (UCSF)
    University of California, San Francisco (UCSF)

    San Francisco, CA

    Key Differentiators

    • Infectious Diseases
    • Molecular Virology
    • Structural Biology

Original Source(s)

Functional and Structural Characterization of Treatment-Emergent Nirmatrelvir Resistance Mutations at Low Frequencies in the Main Protease (Mpro) Reveals a Unique Evolutionary Route for SARS-CoV-2 to Gain Resistance

  • by Natalie M Deschenes, Jimena Pérez-Vargas, Zoe Zhong, Merrilee Thomas, Calem Kenward, Wesley A Mosimann, Liam J Worrall, Nicholas Waglechner, Angel XinLiu Li, Finlay Maguire, Patryk Aftanas, Jason R Smith, Jared Lim, Robert N Young, Artem Cherkasov, Lubna Farooqi, Adnan Moinuddin, Lina Siddiqi, Imaan Malik, Maxime Lefebvre, Mark Paetzel, Natalie C J Strynadka, François Jean, Allison McGeer, Robert A Kozak

  • June 3, 2025

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