Case Report: Primary hemophagocytic lymphohistiocytosis with a homozygous PRF1 variant: a case suggesting early immunoporosis and an expanded phenotypic spectrum - Top-Institutions - MDSpire

Case Report: Primary hemophagocytic lymphohistiocytosis with a homozygous PRF1 variant: a case suggesting early immunoporosis and an expanded phenotypic spectrum

  • By

  • Eman T. Al-Antary

  • Avanti Gupte

  • Süreyya Savaşan

  • June 24, 2026

  • 0 min

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Top Institutions in Hematology

Brief introduction explaining scope and methodology.

  • #1

    Cincinnati Children’s Hospital Medical Center
    Cincinnati Children’s Hospital Medical Center

    Cincinnati, Ohio

    Key Differentiators

    • Hematology
    • Pediatric Oncology

  • #2

    Dana-Farber/Boston Children’s Cancer and Blood Disorders Center
    Dana-Farber/Boston Children’s Cancer and Blood Disorders Center

    Boston, Massachusetts

    Key Differentiators

    • Hematology
    • Pediatric Oncology

  • #3

    Mayo Clinic
    Mayo Clinic

    Rochester, Minnesota

    Key Differentiators

    • Hematology

  • #4

    Xiamen Children's Hospital
    Xiamen Children's Hospital

    Xiamen, Fujian

    Key Differentiators

    • Pediatric Hematology

  • #5

    Erasmus MC
    Erasmus MC

    Rotterdam, South Holland

    Key Differentiators

    • Hematology

Original Source(s)

Case Report: Primary hemophagocytic lymphohistiocytosis with a homozygous PRF1 variant: a case suggesting early immunoporosis and an expanded phenotypic spectrum

  • by Eman T. Al-Antary, Avanti Gupte, Süreyya Savaşan

  • June 24, 2026

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