GLP-1 Analysis: Riding the Wave of Peptide Innovation

The remarkable commercial success of GLP-1 receptor agonists is fueling investment, accelerating science, and creating new analytical challenges. Here, we outline the hurdles these peptides present, explore methods for impurity profiling and structural characterization, and consider strategies to keep pace with this fast-moving field.

By
Amanda M. Guiraldelli
Piotr Alvarez
Koen Sandra
January 26, 2026
17 min

The Analytical Scientist

Top Institutions in Endocrinology

Brief introduction explaining scope and methodology.

#1

Joslin Diabetes Center

Boston, MA
Key Differentiators
- Endocrinology
- Diabetes Research
- Metabolic Diseases
#2

Mayo Clinic

Rochester, MN
Key Differentiators
- Endocrinology
- Obesity Medicine
- Clinical Pharmacology
#3

University of California, San Francisco (UCSF) Medical Center

San Francisco, CA
Key Differentiators
- Endocrinology
- Diabetes and Metabolism
- Pharmacology
#4

Massachusetts General Hospital (MGH)

Boston, MA
Key Differentiators
- Endocrinology
- Diabetes Research
- Translational Medicine
#5

Vanderbilt University Medical Center

Nashville, TN
Key Differentiators
- Endocrinology
- Metabolic Disease Research
- Clinical Trials