Durable response to ALK inhibition in low-allele-frequency SPTBN1–ALK–rearranged gastric cancer followed by lineage plasticity–mediated resistance: a case report - Top-Institutions - MDSpire

Sustained Response to ALK Inhibition in Gastric Cancer with Low-Frequency SPTBN1–ALK Rearrangement and Subsequent Resistance via Lineage Plasticity: A Case Study

  • By

  • Zihua Guan

  • Jiao Liu

  • Wenlu Yu

  • Xu Wang

  • Xinmei Zhang

  • July 21, 2026

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Top Institutions in Oncology

Brief introduction explaining scope and methodology.

  • #1

    Changshan County People’s Hospital
    Changshan County People’s Hospital

    Changshan, Zhejiang

    Key Differentiators

    • Oncology

  • #2

    Memorial Sloan Kettering Cancer Center
    Memorial Sloan Kettering Cancer Center

    New York, New York

    Key Differentiators

    • Oncology

  • #3

    Vanderbilt-Ingram Cancer Center
    Vanderbilt-Ingram Cancer Center

    Nashville, Tennessee

    Key Differentiators

    • Oncology

Original Source(s)

Durable response to ALK inhibition in low-allele-frequency SPTBN1–ALK–rearranged gastric cancer followed by lineage plasticity–mediated resistance: a case report

  • by Zihua Guan, Jiao Liu, Wenlu Yu, Xu Wang, Xinmei Zhang

  • July 21, 2026

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