DNA (cytosine-5)-methyltransferase 3A (Dnmt3a) mutations limit normal and autoreactive CD4+ T follicular helper responses and attenuate T cell-driven joint inflammation - Top-Institutions - MDSpire

Mutations in DNA (cytosine-5)-methyltransferase 3A (Dnmt3a) impair both typical and autoreactive CD4+ T follicular helper cell functions and reduce T cell-mediated joint inflammation

  • By

  • Yunbing Shen

  • Sanjaykumar Boddul

  • Zhaojun Li

  • Zsolt Kasza

  • Marlene Schülein

  • Bruno Raposo

  • Karine Chemin

  • Per-Johan Jakobsson

  • Alexander Espinosa

  • Lars Klareskog

  • Fredrik Wermeling

  • June 29, 2026

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Top Institutions in Rheumatology

Brief introduction explaining scope and methodology.

  • #1

    Karolinska Institutet
    Karolinska Institutet

    Stockholm, Sweden

    Key Differentiators

    • Immunology

  • #2

    Karolinska University Hospital
    Karolinska University Hospital

    Stockholm, Sweden

    Key Differentiators

    • Immunology

  • #3

    American Type Culture Collection
    American Type Culture Collection

    Manassas, Virginia

    Key Differentiators

    • Immunology

  • #4

    Hematology and Hemotherapy Center of the University of Campinas
    Hematology and Hemotherapy Center of the University of Campinas

    Campinas, São Paulo

    Key Differentiators

    • Immunology

  • #5

    University of Tsukuba
    University of Tsukuba

    Tsukuba, Ibaraki

    Key Differentiators

    • Immunology

Original Source(s)

DNA (cytosine-5)-methyltransferase 3A (Dnmt3a) mutations limit normal and autoreactive CD4+ T follicular helper responses and attenuate T cell-driven joint inflammation

  • by Yunbing Shen, Sanjaykumar Boddul, Zhaojun Li, Zsolt Kasza, Marlene Schülein, Bruno Raposo, Karine Chemin, Per-Johan Jakobsson, Alexander Espinosa, Lars Klareskog, Fredrik Wermeling

  • June 29, 2026

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