Case Report: Cortical bone loss, impaired mineralization, and reduced adiposity contributing to chronic bone pain in SFRP4-related skeletal disease with an ALPL variant - Top-Institutions - MDSpire

Case Report: Cortical bone loss, impaired mineralization, and reduced adiposity contributing to chronic bone pain in SFRP4-related skeletal disease with an ALPL variant

  • By

  • Fernando Lizcano

  • Eliana Avilés

  • Cristian López

  • Silvia Maradei-Anaya

  • Maria Camila Ballesteros-García

  • Lizeth Bustamante

  • Fredy Luna

  • Miguel O’Meara

  • Alex Valenzuela

  • June 16, 2026

  • 0 min

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Top Institutions in Endocrinology

Brief introduction explaining scope and methodology.

  • #1

    Hospital for Special Surgery
    Hospital for Special Surgery

    New York, New York

    Key Differentiators

    • Orthopedics
    • Metabolic Bone Disease

  • #2

    Washington University in St. Louis/Barnes‑Jewish Hospital
    Washington University in St. Louis/Barnes‑Jewish Hospital

    St. Louis, Missouri

    Key Differentiators

    • Orthopedics
    • Musculoskeletal Research

Original Source(s)

Case Report: Cortical bone loss, impaired mineralization, and reduced adiposity contributing to chronic bone pain in SFRP4-related skeletal disease with an ALPL variant

  • by Fernando Lizcano, Eliana Avilés, Cristian López, Silvia Maradei-Anaya, Maria Camila Ballesteros-García, Lizeth Bustamante, Fredy Luna, Miguel O’Meara, Alex Valenzuela

  • June 16, 2026

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