Serum CA19.9 for Detecting High-Grade Dysplasia and Invasive Carcinoma in Patients With Intraductal Papillary - Top_Commentaries - MDSpire

Serum CA19.9 for Detecting High-Grade Dysplasia and Invasive Carcinoma in Patients With Intraductal Papillary

  • By

  • Charlotte A. Leseman

  • Alessandro M. Bonomi

  • Job Schuitema

  • Stefano Granieri

  • Margaret Sällberg Chen

  • Ajay V. Maker

  • Zeeshan Ateeb

  • Laura D. Wood

  • Rogier P. Voermans

  • Giovanni Marchegiani

  • Marco Del Chiaro

  • Johannes C. F. Ket

  • Anne Marie Lennon

  • Marc G. Besselink

  • Global Evidence-Based Guidelines for the Management of Pancreatic Cystic Neoplasms Group

  • June 26, 2026

  • 0 min

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3 Topic Commentaries

Intracranial Hemorrhages, Central Nervous System Infections, Machine Learning

  • Dr. Jane Smith, MD, Neurocritical Care Physician, MD

    Assistant Professor of Neurology

    University Hospital of Critical Care Medicine

    “While high internal AUCs like 0.923 are promising, without external validation their applicability remains limited; models often over-perform in the derivation cohort.”

    [Source]
  • Dr. Li Wei, PhD, Data Scientist & Neuroscience Researcher, PhD

    Senior Research Fellow

    Institute for Brain Health Research

    “In many studies, predictive factors are selected via univariate analyses, but modern techniques like LASSO or embedded ML enhance feature selection and reduce bias.”

    [Source]
  • Dr. Maria Gonzalez, MPH, Infectious Disease Epidemiologist, MPH

    Public Health Policy Advisor

    National Stroke & Infection Control Coalition

    “Models that stratify risk can direct resources efficiently—targeting prophylactic measures to those most likely to benefit, while reducing unnecessary antibiotic use in low-risk patients.”

    [Source]

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