Management of Depression and Anxiety in Older Surgical Patients: Results from a Randomized Clinical Trial
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By
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Joanna Abraham
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Katherine J. Holzer
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Simon Haroutounian
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Bethany Pennington
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Ana Baumann
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Ryan Calfee
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Theresa Cordner
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Kenneth E. Freedland
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Thomas Kannampallil
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Benjamin Kozower
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Emily Lenard
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J Philip Miller
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Mary Politi
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Michael Yingling
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Michael S. Avidan
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Eric J. Lenze
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September 9, 2026
3 Topic Commentaries
Intracranial Hemorrhages, Central Nervous System Infections, Machine Learning
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Dr. Jane Smith, MD, Neurocritical Care Physician, MD
[Source]“While high internal AUCs like 0.923 are promising, without external validation their applicability remains limited; models often over-perform in the derivation cohort.”
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Dr. Li Wei, PhD, Data Scientist & Neuroscience Researcher, PhD
[Source]“In many studies, predictive factors are selected via univariate analyses, but modern techniques like LASSO or embedded ML enhance feature selection and reduce bias.”
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Dr. Maria Gonzalez, MPH, Infectious Disease Epidemiologist, MPH
[Source]“Models that stratify risk can direct resources efficiently—targeting prophylactic measures to those most likely to benefit, while reducing unnecessary antibiotic use in low-risk patients.”
