Impact of Pegylated Interferon Addition to Nucleos(t)ide Analogue Treatment on HBsAg Decline and Clearance: A Meta-Analysis of Individual Participant Data from Prospective Trials (PROSPER)
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By
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Edo J Dongelmans
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Lesley A Patmore
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Seng Gee Lim
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Marc Bourliere
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Shaowen Jiang
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Nathalie Ganne-Carrie
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Willem-Pieter Brouwer
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Jordan J Feld
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Yuxian Huang
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Jose A Carrion
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Teresa Broquetas
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Qiankun Hu
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Scott Fung
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Fabrice Carrat
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Fabien Zoulim
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Bettina E Hansen
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Qing Xie
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Harry L A Janssen
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Milan J Sonneveld
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October 1, 2026
3 Topic Commentaries
Intracranial Hemorrhages, Central Nervous System Infections, Machine Learning
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Dr. Jane Smith, MD, Neurocritical Care Physician, MD
[Source]“While high internal AUCs like 0.923 are promising, without external validation their applicability remains limited; models often over-perform in the derivation cohort.”
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Dr. Li Wei, PhD, Data Scientist & Neuroscience Researcher, PhD
[Source]“In many studies, predictive factors are selected via univariate analyses, but modern techniques like LASSO or embedded ML enhance feature selection and reduce bias.”
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Dr. Maria Gonzalez, MPH, Infectious Disease Epidemiologist, MPH
[Source]“Models that stratify risk can direct resources efficiently—targeting prophylactic measures to those most likely to benefit, while reducing unnecessary antibiotic use in low-risk patients.”
