Development of Multi-Spheroid Bone Constructs via the Combination of Large MSC Spheroids
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By
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Peter Zastawny
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Stephen D. Waldman
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September 21, 2026
3 Topic Commentaries
Intracranial Hemorrhages, Central Nervous System Infections, Machine Learning
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Dr. Jane Smith, MD, Neurocritical Care Physician, MD
Assistant Professor of Neurology
•University Hospital of Critical Care Medicine
[Source]“While high internal AUCs like 0.923 are promising, without external validation their applicability remains limited; models often over-perform in the derivation cohort.”
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Dr. Li Wei, PhD, Data Scientist & Neuroscience Researcher, PhD
Senior Research Fellow
•Institute for Brain Health Research
[Source]“In many studies, predictive factors are selected via univariate analyses, but modern techniques like LASSO or embedded ML enhance feature selection and reduce bias.”
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Dr. Maria Gonzalez, MPH, Infectious Disease Epidemiologist, MPH
Public Health Policy Advisor
•National Stroke & Infection Control Coalition
[Source]“Models that stratify risk can direct resources efficiently—targeting prophylactic measures to those most likely to benefit, while reducing unnecessary antibiotic use in low-risk patients.”
Based on findings from:
Engineering Multi-Spheroid Bone Constructs Through the Fusion of Large MSC Spheroids
Peter Zastawny, Stephen D. Waldman. Journal Of Orthopaedic Research, 2026.
https://onlinelibrary.wiley.com/doi/10.1002/jor.70280
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