Prognostic impact of need for re-induction based on day-14 residual disease and age-adapted consolidation strategy in acute myeloid leukemia - Top_Commentaries - MDSpire
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Prognostic Significance of Re-Induction Necessity Based on Day-14 Residual Disease and Age-Adjusted Consolidation Approaches in Acute Myeloid Leukemia

  • By

  • Abiola Bolarinwa

  • Muhammad Yousuf

  • Aref Al-Kali

  • Hassan B. Alkhateeb

  • Abhishek A. Mangaonkar

  • Antoine N. Saliba

  • Mehrdad Hefazi Torghabeh

  • Aasiya Matin

  • Michelle A. Elliott

  • Mark R. Litzow

  • William J. Hogan

  • Mithun V. Shah

  • Mrinal M. Patnaik

  • Animesh Pardanani

  • Dong Chen

  • Kaaren K. Reichard

  • Rong He

  • Naseema Gangat

  • Ayalew Tefferi

  • Kebede H. Begna

  • September 30, 2026

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3 Topic Commentaries

Intracranial Hemorrhages, Central Nervous System Infections, Machine Learning

  • Dr. Jane Smith, MD, Neurocritical Care Physician, MD

    Assistant Professor of Neurology

    •

    University Hospital of Critical Care Medicine

    “While high internal AUCs like 0.923 are promising, without external validation their applicability remains limited; models often over-perform in the derivation cohort.”

    [Source]
  • Dr. Li Wei, PhD, Data Scientist & Neuroscience Researcher, PhD

    Senior Research Fellow

    •

    Institute for Brain Health Research

    “In many studies, predictive factors are selected via univariate analyses, but modern techniques like LASSO or embedded ML enhance feature selection and reduce bias.”

    [Source]
  • Dr. Maria Gonzalez, MPH, Infectious Disease Epidemiologist, MPH

    Public Health Policy Advisor

    •

    National Stroke & Infection Control Coalition

    “Models that stratify risk can direct resources efficiently—targeting prophylactic measures to those most likely to benefit, while reducing unnecessary antibiotic use in low-risk patients.”

    [Source]

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