Analysis of HPV Vaccination Effects on CIN2+ Recurrence Following Conization: A Systematic Review and Meta-Analysis of Timing, Valency, and Surgical Margins
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By
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Mengjie Xue
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Jihong Peng
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August 24, 2026
3 Topic Commentaries
Intracranial Hemorrhages, Central Nervous System Infections, Machine Learning
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Dr. Jane Smith, MD, Neurocritical Care Physician, MD
Assistant Professor of Neurology
•University Hospital of Critical Care Medicine
[Source]“While high internal AUCs like 0.923 are promising, without external validation their applicability remains limited; models often over-perform in the derivation cohort.”
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Dr. Li Wei, PhD, Data Scientist & Neuroscience Researcher, PhD
Senior Research Fellow
•Institute for Brain Health Research
[Source]“In many studies, predictive factors are selected via univariate analyses, but modern techniques like LASSO or embedded ML enhance feature selection and reduce bias.”
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Dr. Maria Gonzalez, MPH, Infectious Disease Epidemiologist, MPH
Public Health Policy Advisor
•National Stroke & Infection Control Coalition
[Source]“Models that stratify risk can direct resources efficiently—targeting prophylactic measures to those most likely to benefit, while reducing unnecessary antibiotic use in low-risk patients.”
Based on findings from:
Commentary: Impact of HPV vaccine on CIN2+ recurrence after conization: a systematic review and meta-analysis of vaccination timing, valency and surgical margins
Mengjie Xue, Jihong Peng. Frontiers In Oncology, 2026.
https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2026.1914736/full
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