Factors associated with 90-day mortality in adults with cryptococcal meningoencephalitis across HIV, solid organ transplant, and non-HIV, non-transplant populations - Top_Commentaries - MDSpire
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Determinants of 90-Day Mortality in Adults with Cryptococcal Meningoencephalitis in HIV, Solid Organ Transplant, and Non-HIV, Non-Transplant Groups

  • By

  • Bayard A. Taylor

  • Ameera Jamshad

  • Andrés F. Henao-Martínez

  • Charlie Garcia

  • David B. Cluck

  • Daniel B. Chastain

  • October 5, 2026

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3 Topic Commentaries

Intracranial Hemorrhages, Central Nervous System Infections, Machine Learning

  • Dr. Jane Smith, MD, Neurocritical Care Physician, MD

    Assistant Professor of Neurology

    •

    University Hospital of Critical Care Medicine

    “While high internal AUCs like 0.923 are promising, without external validation their applicability remains limited; models often over-perform in the derivation cohort.”

    [Source]
  • Dr. Li Wei, PhD, Data Scientist & Neuroscience Researcher, PhD

    Senior Research Fellow

    •

    Institute for Brain Health Research

    “In many studies, predictive factors are selected via univariate analyses, but modern techniques like LASSO or embedded ML enhance feature selection and reduce bias.”

    [Source]
  • Dr. Maria Gonzalez, MPH, Infectious Disease Epidemiologist, MPH

    Public Health Policy Advisor

    •

    National Stroke & Infection Control Coalition

    “Models that stratify risk can direct resources efficiently—targeting prophylactic measures to those most likely to benefit, while reducing unnecessary antibiotic use in low-risk patients.”

    [Source]

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