The Use of Waivers of Guardian Permission in the United States for Pediatric Digital Health Intervention Research Since 2020: Systematic Review - Top_Commentaries - MDSpire
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Examining Guardian Permission Waivers for Pediatric Digital Health Research in the U.S. Since 2020: A Systematic Review

  • By

  • Colleen Stiles-Shields

  • Elyse Shenberger

  • Ann Bernica

  • Gabriella Bobadilla

  • Kandis Fletcher

  • Jasmine George

  • Sydney Gordon

  • Erika L Gustafson

  • Crystal S Hernandez

  • Taylor L Hilderbrand

  • Sarah N Kumi

  • Christine A Lee

  • Sarah I Lorduy

  • Meera Phanse

  • Lauren M Potthoff

  • Naomi Quezada

  • Dale L Smith

  • Holly J Hudson

  • Emily E Anderson

  • September 25, 2026

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3 Topic Commentaries

Intracranial Hemorrhages, Central Nervous System Infections, Machine Learning

  • Dr. Jane Smith, MD, Neurocritical Care Physician, MD

    Assistant Professor of Neurology

    •

    University Hospital of Critical Care Medicine

    “While high internal AUCs like 0.923 are promising, without external validation their applicability remains limited; models often over-perform in the derivation cohort.”

    [Source]
  • Dr. Li Wei, PhD, Data Scientist & Neuroscience Researcher, PhD

    Senior Research Fellow

    •

    Institute for Brain Health Research

    “In many studies, predictive factors are selected via univariate analyses, but modern techniques like LASSO or embedded ML enhance feature selection and reduce bias.”

    [Source]
  • Dr. Maria Gonzalez, MPH, Infectious Disease Epidemiologist, MPH

    Public Health Policy Advisor

    •

    National Stroke & Infection Control Coalition

    “Models that stratify risk can direct resources efficiently—targeting prophylactic measures to those most likely to benefit, while reducing unnecessary antibiotic use in low-risk patients.”

    [Source]

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