High levels of cell-free hemoglobin and iron in cerebral thrombi of pre-Omicron COVID-19 stroke patients: novel drivers of SARS-CoV-2–induced prothrombotic state - Top_Commentaries - MDSpire
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Elevated concentrations of cell-free hemoglobin and iron found in cerebral thrombi of stroke patients prior to the Omicron variant: new contributors to the prothrombotic effects of SARS-CoV-2

  • By

  • María Payá

  • Cristian Alcahut-Rodríguez

  • Rosa A. Barbella-Aponte

  • Francisco Hernández-Fernández

  • Juan D. Molina-Nuevo

  • Gemma Barroso-García

  • Beatriz Castro-Robles

  • Susana López-López

  • Lourdes Arias-Salazar

  • Óscar Ayo-Martín

  • Jorge García-García

  • Blanca Yélamos-Sanz

  • Natalia García-Flores

  • Alba G. Arandilla

  • Rafael Moreno-Luna

  • Alicia Aliena-Valero

  • Isabel Vielba-Gómez

  • José I. Tembl

  • Juan B. Salom

  • Gemma Serrano-Heras

  • Tomás Segura

  • August 29, 2026

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3 Topic Commentaries

Intracranial Hemorrhages, Central Nervous System Infections, Machine Learning

  • Dr. Jane Smith, MD, Neurocritical Care Physician, MD

    Assistant Professor of Neurology

    University Hospital of Critical Care Medicine

    “While high internal AUCs like 0.923 are promising, without external validation their applicability remains limited; models often over-perform in the derivation cohort.”

    [Source]
  • Dr. Li Wei, PhD, Data Scientist & Neuroscience Researcher, PhD

    Senior Research Fellow

    Institute for Brain Health Research

    “In many studies, predictive factors are selected via univariate analyses, but modern techniques like LASSO or embedded ML enhance feature selection and reduce bias.”

    [Source]
  • Dr. Maria Gonzalez, MPH, Infectious Disease Epidemiologist, MPH

    Public Health Policy Advisor

    National Stroke & Infection Control Coalition

    “Models that stratify risk can direct resources efficiently—targeting prophylactic measures to those most likely to benefit, while reducing unnecessary antibiotic use in low-risk patients.”

    [Source]

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