Association Between ADHD Medication and Self-Harm Risk: A Multinational Self-Controlled Case Series Analysis
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By
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Adrienne Y L Chan
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Kebede Beyene
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Sohee Park
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Chin-Yao Shen
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Andrew S C Yuen
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Kirstie H T W Wong
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Shiu Lun Au Yeung
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Esther W Chan
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David Coghill
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Celine S L Chui
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Sharon Cook
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Stephen Crystal
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Patrick Ip
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Tatia M C Lee
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Wallis C Y Lau
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Xue Li
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Terry Y S Lum
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Hao Luo
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Nirmala Rao
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Andrew Tomlin
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Li Wei
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Yun K Wing
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Amy H Y Chan
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Edward Chia-Cheng Lai
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Ju-Young Shin
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Kenneth K C Man
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Ian C K Wong
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September 12, 2026
3 Topic Commentaries
Intracranial Hemorrhages, Central Nervous System Infections, Machine Learning
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Dr. Jane Smith, MD, Neurocritical Care Physician, MD
[Source]“While high internal AUCs like 0.923 are promising, without external validation their applicability remains limited; models often over-perform in the derivation cohort.”
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Dr. Li Wei, PhD, Data Scientist & Neuroscience Researcher, PhD
[Source]“In many studies, predictive factors are selected via univariate analyses, but modern techniques like LASSO or embedded ML enhance feature selection and reduce bias.”
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Dr. Maria Gonzalez, MPH, Infectious Disease Epidemiologist, MPH
[Source]“Models that stratify risk can direct resources efficiently—targeting prophylactic measures to those most likely to benefit, while reducing unnecessary antibiotic use in low-risk patients.”
